慢性阻塞性肺疾病(COPD)是一种普遍的呼吸系统疾病,具有全球意义。准确和及时的诊断是至关重要的;然而,传统的诊断方法(基于肺活量测定)显示出局限性,促使人们寻找预测性生物标志物和现代诊断技术。本研究探索了COPD相关生物标志物(C反应蛋白,降钙素原,中性粒细胞弹性蛋白酶,和唾液中的α-1抗胰蛋白酶)。一个多样化的群体,包括健康的非吸烟者,健康的吸烟者,和波兰血统的COPD患者,进行了肺活量测定和标记分析。数据与临床因素相关,揭示值得注意的关系。首先,将唾液生物标志物水平与血清浓度进行比较,表现出显著的正相关或负相关,取决于因素。对健康个体的进一步分析揭示了生物标志物水平之间的关联,肺活量测定,和临床特征,如年龄,性别,BMI。接下来,与健康组相比,COPD患者表现出增加的生物标志物浓度。最后,这项研究引入了一项呼吸评估调查,揭示了自我感知的呼吸和肺活量测定与测试参数之间的显着关联。结果强调了COPD研究中主观经验的相关性。总之,这项研究强调了唾液生物标志物作为COPD诊断工具的潜力,提供传统方法的非侵入性和可访问的替代方案。这些发现为改进现代诊断方法铺平了道路。
Chronic obstructive pulmonary disease (
COPD) is a prevalent respiratory condition with global implications. Accurate and timely diagnosis is critical; however, traditional diagnostic methods (based on spirometry) show limitations, prompting the search for predictive biomarkers and modern diagnostic techniques. This study explored the validation of
COPD-related biomarkers (C-reactive protein, procalcitonin, neutrophil elastase, and alpha-1 antitrypsin) in saliva. A diverse cohort, including healthy non-smokers, healthy smokers, and
COPD patients of Polish origin, underwent spirometry and marker analysis. The data correlated with clinical factors, revealing noteworthy relations. Firstly, salivary biomarker levels were compared with serum concentrations, demonstrating notable positive or negative correlations, depending on the factor. Further analysis within healthy individuals revealed associations between biomarker levels, spirometry, and clinical characteristics such as age, sex, and BMI. Next,
COPD patients exhibited an enhanced concentration of biomarkers compared to healthy groups. Finally, the study introduced a breathing assessment survey, unveiling significant associations between self-perceived breathing and spirometric and tested parameters. Outcomes emphasized the relevance of subjective experiences in
COPD research. In conclusion, this research underscored the potential of salivary biomarkers as diagnostic tools for COPD, offering a non-invasive and accessible alternative to traditional methods. The findings paved the way for improved modern diagnostic approaches.